Journal: ACS Chemical Biology

Article Title: Antimicrobial Agent Trimethoprim Influences Chemical Interactions in Cystic Fibrosis Pathogens via the ham Gene Cluster

doi: 10.1021/acschembio.4c00562

Figure Lengend Snippet: Fungal siderophore triacetylfusarinin C detected upon cocultivation of A. fumigatus and B. cenocepacia . (a) Molecular network of TAFC analogues connected via FBMN or MS2LDA. (b) Mass2Motif 559 corresponding to the TAFC substructure. (c) Boxplots of the relative abundance of TAFC and TAFC-iron complex in extracts derived from A. fumigatus monocultures and A. fumigatus + B. cenocepacia cocultures in the presence and absence of trimethoprim. Asterisks indicate the significant differences between the compared groups, as determined by the Kruskal–Wallis test with Dunn’s post-test (adjusted p -value <0.05). (d) MALDI-MSI-derived images for TAFC in mono- and cocultures. The visualization of the spatial distribution of TAFC is shown as a heatmap in false color (cyan, m / z 875.401, [M + Na] + ). A white rectangle represents the measurement area used for data acquisition.

Article Snippet: Boxplots were created for features of interest in RStudio using the nonparametric Kruskal–Wallis test with Dunn’s post-test for significance levels between groups.

Techniques: Analogues, Derivative Assay

Journal: ACS Chemical Biology

Article Title: Antimicrobial Agent Trimethoprim Influences Chemical Interactions in Cystic Fibrosis Pathogens via the ham Gene Cluster

doi: 10.1021/acschembio.4c00562

Figure Lengend Snippet: Shift in chemical interactions between B. cenocepacia and A. fumigatus in the absence of the functional ham gene cluster. Boxplots of the relative abundance of (a) triacetylfusarinin C, (b) the ergosterol-related compound with m / z 496.415, (c) the unknown compound 1 with m / z 318.202, and (d) the unknown compound 2 with m / z 304.223 in the extracts derived from A. fumigatus monocultures and cocultures with either B. cenocepacia WT or Δ hamC strains in the presence and absence of sublethal trimethoprim.

Article Snippet: Boxplots were created for features of interest in RStudio using the nonparametric Kruskal–Wallis test with Dunn’s post-test for significance levels between groups.

Techniques: Functional Assay, Derivative Assay

Journal: Toxins

Article Title: Minimizing Ochratoxin A Contamination through the Use of Actinobacteria and Their Active Molecules

doi: 10.3390/toxins12050296

Figure Lengend Snippet: Degradation of ochratoxin A by bacterial cells after 10 days of culture at 25 °C in solid and liquid medium, and by unheated CFEs after 48 h at 25 °C under agitation (180 rpm). Boxplots represent the distribution of the degradation efficiency given in % of the control. The control was performed by adding the toxin in CYA or CYB medium without bacteria and incubated in the same conditions as the samples.

Article Snippet: Boxplots and Pearson correlation graphics were developed in Rstudio.

Techniques: Control, Bacteria, Incubation

Journal: Journal of Neurophysiology

Article Title: StartReact effects are dependent on engagement of startle reflex circuits: support for a subcortically mediated initiation pathway

doi: 10.1152/jn.00505.2019

Figure Lengend Snippet: Premotor reaction time (RT) as a function of experimental trial type. A: boxplots of participant mean RT in control [non-startling acoustic stimulus (non-SAS): 80-dB stimulus] and SAS trials, where SCM− represents SAS trials where no startle response in sternocleidomastoid (SCM) was elicited and SCM+ represents SAS trials where a startle response in SCM was elicited. Box boundaries show the first and third quartiles, whereas the thick line shows the median. Whiskers show the minimum and maximum values within 1.5 times the interquartile range, and small circles show values outside this range (outliers). *P < 0.05, significant differences between conditions detected using linear mixed effects (LME) analysis and Tukey’s method for multiple comparisons. B: individual data points used in the linear mixed effects analysis of RT as a function of trial type. Line shows fitted LME model and 95% confidence interval (n = 12). Note 3 data points >250 ms were omitted in the control condition.

Article Snippet: A : boxplots of participant mean RT in control [non-startling acoustic stimulus (non-SAS): 80-dB stimulus] and SAS trials, where SCM− represents SAS trials where no startle response in sternocleidomastoid (SCM) was elicited and SCM+ represents SAS trials where a startle response in SCM was elicited.

Techniques: Control

Journal: Journal of Neurophysiology

Article Title: StartReact effects are dependent on engagement of startle reflex circuits: support for a subcortically mediated initiation pathway

doi: 10.1152/jn.00505.2019

Figure Lengend Snippet: Motor-evoked potential (MEP) peak-to-peak amplitude in control and startling acoustic stimulus (SAS) trials. A: boxplots of participant mean MEP amplitude in control (non-SAS: 80-dB stimulus) trials and SAS trials, where SCM− shows SAS trials where a startle response in sternocleidomastoid (SCM) was not elicited and SCM+ shows SAS where a startle response in SCM was elicited. Box boundaries show the first and third quartiles, whereas the thick line shows the median. Whiskers show the minimum and maximum values within 1.5 times the interquartile range. Individual participant mean values across conditions are shown as gray lines. Mean MEP amplitude between SCM+ and SCM− was shown to be statistically equivalent by using the two one-sided test procedure. B: individual data points used in the linear mixed effects (LME) analysis of MEP amplitude as a function of trial type. Line shows fitted LME model and 95% confidence interval (n = 12).

Article Snippet: A : boxplots of participant mean RT in control [non-startling acoustic stimulus (non-SAS): 80-dB stimulus] and SAS trials, where SCM− represents SAS trials where no startle response in sternocleidomastoid (SCM) was elicited and SCM+ represents SAS trials where a startle response in SCM was elicited.

Techniques: Control

Journal: Scientific Reports

Article Title: Revisiting the hyperdominance of Neotropical tree species under a taxonomic, functional and evolutionary perspective

doi: 10.1038/s41598-021-88417-y

Figure Lengend Snippet: High trait variability among different populations of Protium heptaphyllum s.l . (A) Leaf and wood trait variation for multiple populations of P. heptaphyllum s.l. and color-coded by the genetic clusters identified by STRUCTURE analysis. The results confirm high variability within each population and among putatively discovered lineages. Functional traits were mapped onto a collapsed phylogeny including 24 geographically widespread populations. See Table for complementary details about individual samples and Fig. to access their geographic location. Boxplot graphs generated in RStudio version 1.1.447 ( https://rstudio.com/products/rstudio/ ).

Article Snippet: Boxplot graphs generated in RStudio version 1.1.447 ( https://rstudio.com/products/rstudio/ ).

Techniques: Functional Assay, Generated